Toxicity in Rhesus Monkeys Following Administration of the 8-Aminoquinoline 8-[(4-amino-l-methylbutyl)amino]-5(l-hexyloxy)-6-methoxy-4-methylquinoline (WR242511)

Many substances that form methemoglobin (MHb) effectively counter cyanide (CN) toxicity. Although MHb formers are generally applied as treatments for CN poisoning, it has been proposed that a stable, long-acting MHb former could serve as a CN pretreatment. Using this rationale, the 8-aminoquinoline...

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Bibliographic Details
Main Authors: Rockwood, Gary A, Duniho, Steven M, Briscoe, Crystal M, Gold, Mark B, Armstrong, Kevin R, Moran, Anita V, Kahler, David W, Baskin, Steven I
Format: Report
Language:English
Subjects:
8-AMINOQUINOLINES
AMINO ACIDS
Biochemistry
Biology
DOGS
METHEMOGLOBIN
POISONING
PRETREATMENT
RHESUS MONKEYS
RODENTS
TOXICITY
Toxicology
WR242511
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Summary:Many substances that form methemoglobin (MHb) effectively counter cyanide (CN) toxicity. Although MHb formers are generally applied as treatments for CN poisoning, it has been proposed that a stable, long-acting MHb former could serve as a CN pretreatment. Using this rationale, the 8-aminoquinoline WR242511, a potent long-lasting MHb former in rodents and beagle dogs, was studied in the rhesus monkey for advanced development as a potential CN pretreatment. The original document contains color images.