Antibodies to Squalene in US Navy Persian Gulf War Veterans with Chronic Multisymptom Illness

Since the end of the 1991 Gulf War, there have been reports of unexplained, multisymptom illnesses afflicting veterans who consistently report more symptoms than do nondeployed veterans. One of the many possible exposures suspected of causing chronic multisymptom illnesses Gulf War veterans is squal...

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Bibliographic Details
Main Authors: Phillips, Christopher J, Matyas, Gary R, Hansen, Christian J, Alving, Carl R, Smith, Tyler C, Ryan, Margaret A
Format: Report
Language:English
Subjects:
ANTIBODIES
DEPLOYMENT
Medicine and Medical Research
MULTISYMPTOM ILLNESSES
NAVAL PERSONNEL
OCCUPATIONAL DISEASES
PERSIAN GULF WAR
REPRINTS
SEABEES
SIGNS AND SYMPTOMS
SQUALENE
VACCINES
VETERANS(MILITARY PERSONNEL)
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Summary:Since the end of the 1991 Gulf War, there have been reports of unexplained, multisymptom illnesses afflicting veterans who consistently report more symptoms than do nondeployed veterans. One of the many possible exposures suspected of causing chronic multisymptom illnesses Gulf War veterans is squalene, thought to be present in anthrax vaccine. We examined the relationship between squalene antibodies and chronic symptoms reported by Navy construction workers (Seabees), n = 579. 30.2% were deployers, 7.4% were defined as ill, and 43.5% were positive for squalene antibodies. We found no association between squalene antibody status and chronic multisymptom illness (p = 0.465). The etiology of Gulf War syndrome remains unknown, but should not include squalene antibody status. Work unit no. 6002. Published in Vaccine, v27 p3921-3926, 12 June 2009. ISSN 0264-410X