The Oxime Pro-2-PAM Provides Minimal Protection Against the CNS Effects of the Nerve Agents Sarin, Cyclosarin, and VX in Guinea Pigs

Chemical warfare nerve agents and certain pesticides are organophosphorus compounds (OPs) that potently inhibit cholinesterases (ChEs), in particular acetylcholinesterase (AChE), an enzyme that hydrolyzes the cholinergic neurotransmitter acetylcholine (ACh) in the peripheral and central nervous syst...

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Bibliographic Details
Main Authors: Shih, Tsung-Ming, Guarisco, John A, Myers, Todd M, Kan, Robert K, McDonough, John H
Format: Report
Language:English
Subjects:
ACETYLCHOLINESTERASE
Anatomy and Physiology
Biochemistry
CENTRAL NERVOUS SYSTEM
CHEMICAL WARFARE AGENTS
CYCLOSARIN
ENZYMES
GB AGENT
GUINEA PIGS
NERVE AGENTS
NEUROTRANSMITTERS
ORGANIC PHOSPHORUS COMPOUNDS
OXIMES
PESTICIDES
REPRINTS
VX AGENT
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Summary:Chemical warfare nerve agents and certain pesticides are organophosphorus compounds (OPs) that potently inhibit cholinesterases (ChEs), in particular acetylcholinesterase (AChE), an enzyme that hydrolyzes the cholinergic neurotransmitter acetylcholine (ACh) in the peripheral and central nervous system (CNS) (Taylor 2001). Published in Toxicology Mechnisms and Methods, v21 n1 p53-62, 2011. The original document contains color images.