Mechanism and Therapy for the Shared Susceptibility to Migraine and Epilepsy after Traumatic Brain Injury

Our proposal studies the natural history and mechanisms of increased brain excitability leading to migraine and epilepsy after traumatic brain injury. In the 6 months since this grant was funded, we have performed experiments spanning nearly the whole range of our proposed work. The most important m...

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Bibliographic Details
Main Authors: Brennan, K C, Dudek, Ed, Pouliot, Wendy, Vargas, Jay, Mendez, Jorge M, Sawant, Punam
Format: Report
Language:English
Subjects:
BRAIN
CORTICAL SPREADING DEPRESSION
CUTTERS
DATA ACQUISITION
EPILEPSY
IMMUNOLOGY
Medicine and Medical Research
MICROSCOPY
MIGRAINE
MONITORING
NATURAL HISTORY
OPTICAL IMAGES
PHOTONS
POST-TRAUMATIC EPILEPSY
POST-TRAUMATIC HEADACHE
REMOTE DETECTION
SEIZURE
Stress Physiology
TELEMETER SYSTEMS
THERAPY
TRAUMA
TRAUMATIC BRAIN INJURIES
WOUNDS AND INJURIES
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Summary:Our proposal studies the natural history and mechanisms of increased brain excitability leading to migraine and epilepsy after traumatic brain injury. In the 6 months since this grant was funded, we have performed experiments spanning nearly the whole range of our proposed work. The most important milestones have been the validation and beginning of data collection for remote telemetric monitoring and two-photon microscopy. These are both technology-intensive, cutting edge techniques, and two-photon microscopy was a new technique for our group. We have also collected publication-ready work using our more familiar optical imaging techniques, showing that the immunological activation associated with TBI alters brain excitability.