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Mechanism and Therapy for the Shared Susceptibility to Migraine and Epilepsy after Traumatic Brain Injury

Our proposal studies the natural history and mechanisms of increased brain excitability leading to migraine and epilepsy after traumatic brain injury. In the 6 months since this grant was funded, we have performed experiments spanning nearly the whole range of our proposed work. The most important m...

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Main Authors:	Brennan, K C, Dudek, Ed, Pouliot, Wendy, Vargas, Jay, Mendez, Jorge M, Sawant, Punam
Format:	Report
Language:	English
Subjects:	BRAIN CORTICAL SPREADING DEPRESSION CUTTERS DATA ACQUISITION EPILEPSY IMMUNOLOGY Medicine and Medical Research MICROSCOPY MIGRAINE MONITORING NATURAL HISTORY OPTICAL IMAGES PHOTONS POST-TRAUMATIC EPILEPSY POST-TRAUMATIC HEADACHE REMOTE DETECTION SEIZURE Stress Physiology TELEMETER SYSTEMS THERAPY TRAUMA TRAUMATIC BRAIN INJURIES WOUNDS AND INJURIES
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creator	Brennan, K C Dudek, Ed Pouliot, Wendy Vargas, Jay Mendez, Jorge M Sawant, Punam
description	Our proposal studies the natural history and mechanisms of increased brain excitability leading to migraine and epilepsy after traumatic brain injury. In the 6 months since this grant was funded, we have performed experiments spanning nearly the whole range of our proposed work. The most important milestones have been the validation and beginning of data collection for remote telemetric monitoring and two-photon microscopy. These are both technology-intensive, cutting edge techniques, and two-photon microscopy was a new technique for our group. We have also collected publication-ready work using our more familiar optical imaging techniques, showing that the immunological activation associated with TBI alters brain excitability.
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source	DTIC Technical Reports
subjects	BRAIN CORTICAL SPREADING DEPRESSION CUTTERS DATA ACQUISITION EPILEPSY IMMUNOLOGY Medicine and Medical Research MICROSCOPY MIGRAINE MONITORING NATURAL HISTORY OPTICAL IMAGES PHOTONS POST-TRAUMATIC EPILEPSY POST-TRAUMATIC HEADACHE REMOTE DETECTION SEIZURE Stress Physiology TELEMETER SYSTEMS THERAPY TRAUMA TRAUMATIC BRAIN INJURIES WOUNDS AND INJURIES
title	Mechanism and Therapy for the Shared Susceptibility to Migraine and Epilepsy after Traumatic Brain Injury
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