Prevention of Blast-Related Injuries

This report covers work done on blast testing of live anesthetized swine and on unembalmed cadavers. A detailed histological study of blast-exposed swine brain showed that there was damage to both the axons and the neuron cell bodies in the form beta-APP immunoreactivity and other tests, suggesting...

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Bibliographic Details
Main Authors: King, Albert I, Cavanaugh, John, Yang, King, Zhang, Liying, Jin, Xin, Zhu, Feng
Format: Report
Language:English
Subjects:
Anatomy and Physiology
AXONS
BLAST
BLAST TESTING
BLAST-RELATED BRAIN INJURY
BRAIN
BRAIN INJURY MECHANISMS
COMPUTER MODELING OF SWINE AND HUMAN BRAIN
COMPUTERIZED SIMULATION
ELECTROENCEPHALOGRAPHY
Explosions
FIELD TESTS
HISTOLOGY
IOP(INCIDENT OVERPRESSURE)
MAGNETIC RESONANCE IMAGING
Medicine and Medical Research
MRI(MAGNETIC RESONANCE IMAGING)
NERVE CELLS
OPEN FIELD TESTING OF SWINE AND PMHS
OVERPRESSURE
PMHS(POST-MORTEM HUMAN SUBJECTS)
PREVENTION
QEEG(QUANTITATIVE ELECTROENCEPHALOGRAPHY)
SWINE
VALIDATION
WOUNDS AND INJURIES
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Summary:This report covers work done on blast testing of live anesthetized swine and on unembalmed cadavers. A detailed histological study of blast-exposed swine brain showed that there was damage to both the axons and the neuron cell bodies in the form beta-APP immunoreactivity and other tests, suggesting that the mechanism of injury may be different from that of blunt impact. We have also developed computer models of the swine and human brain and are in the process of validating them against the acquired experimental data. It is proposed that future research concentrate on seeking injury mechanisms to brain cells caused by a pressure wave. The original document contains color images.