Contribution of Bacterial and Viral infections to Attributable Mortality in Patients with Severe Burns: An Autopsy Series

Bacterial infections are a common cause of mortality in burn patients and viral infections, notable herpes simplex virus (HSV) and cytomegalovirus (CMV) have also been associated with mortality. This study is a retrospective review of all autopsy reports from patients with severe thermal burns treat...

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Bibliographic Details
Main Authors: D'Avignon, Laurie C, Hogan, Brian K, Murray, Clinton K, Loo, Florence L, Hospenthal, Duane R, Cancio, Leopoldo C, Kim, Seung H, Renz, Evan M, Barillo, David, Holcomb, John B
Format: Report
Language:English
Subjects:
Anatomy and Physiology
AUTOPSY
BACTERIA
BACTERIAL DISEASES
BACTERIAL INFECTIONS
BURNS(INJURIES)
COLONIES(BIOLOGY)
CYTOMEGALOVIRUS
DEMOGRAPHY
EMERGENCY MEDICINE
ESCHERICHIA COLI
EXPOSURE(PHYSIOLOGY)
HERPES SIMPLEX VIRUS
INFECTIOUS DISEASES
INHALATION
KLEBSIELLA PNEUMONIAE
Medicine and Medical Research
Microbiology
MORTALITY RATE
PATHOGENIC MICROORGANISMS
PATIENTS
PSEUDOMONAS AERUGINOSA
REPRINTS
STAPHYLOCOCCUS AUREUS
SURVIVABILITY
VIRAL INFECTIONS
VIRUS DISEASES
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Summary:Bacterial infections are a common cause of mortality in burn patients and viral infections, notable herpes simplex virus (HSV) and cytomegalovirus (CMV) have also been associated with mortality. This study is a retrospective review of all autopsy reports from patients with severe thermal burns treated at the US Army Institute of Research (USAISR) burn unit over 12 years. The review focused on those patients with death attributed to a bacterial or viral cause by autopsy report. Of 3751 admissions, 228 patients died with 97 undergoing autopsy. Death was attributed to bacteria for 27 patients and to virus for 5 patients. Bacterial pathogens associated with mortality included Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus. This association with mortality was independent of % total body surface area burn, % full thickness burn, inhalation injury and day of death post burn. Published in Burns, v36 p773-779, 2010.