Study of 'Penicillin' Antibodies by Fluorescence Polarization and Immunodiffusion

It has been shown that human allergic responses following administration of penicillin are usually correlated with the presence of circulating antibodies to derivatives of this antibiotic. The careful chemical studies by Levine et al de Weck and Parker have shown that these antibodies are most often...

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Bibliographic Details
Main Authors: Halbert, S. P, Dandliker, W. B, Florin, M. C, Alonso, R, Shapiro, H. C
Format: Report
Language:English
Subjects:
ANTIBODIES
ANTIGENS
BIOCHEMISTRY
CHEMISTRY
DIFFUSION
FLUORESCENCE
IMMUNITY
Immunodiffusion
IN VIVO ANALYSIS
Medical Facilities, Equipment and Supplies
PENICILLINS
Pharmacology
POLARIZATION
PROTEINS
U/A Reports
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Summary:It has been shown that human allergic responses following administration of penicillin are usually correlated with the presence of circulating antibodies to derivatives of this antibiotic. The careful chemical studies by Levine et al de Weck and Parker have shown that these antibodies are most often directed against the penicilloyl determinant group, although other determinants may sometimes be involved. Antigenicity appears to be conferred upon this molecule following its in vivo conjugation with proteins derived from tissues. Keywords: U/A Reports, Penicillin, Antibodies, Fluorescence polarization, Immunodiffusion, Pharmacology, Biochemistry. (jg)