Studies on Biological Actions of Dimethyl Sulfoxide in Familial Amyloidosis

Dimethyl sulfoxide (DMSO) had not been regarded as a therapeutic drug against amyloidosis until 1974 when Osserman and Isobe administered it for the first time in six cases of primary amyloidosis. In 1973, we described an outline of the second largest concentration of familial amyloid polyneuropathy...

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Bibliographic Details
Main Authors: Kito,Shozo, Itoga,Eiko, Inokawa,Masae, Hironaka,Masatoshi, Kishida,Takenobu
Format: Report
Language:English
Subjects:
Amyloidosis
Chemotherapy
Component reports
Dimethyl sulfoxide
In vitro analysis
Methyl sulfoxide
Patients
Symposia
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Summary:Dimethyl sulfoxide (DMSO) had not been regarded as a therapeutic drug against amyloidosis until 1974 when Osserman and Isobe administered it for the first time in six cases of primary amyloidosis. In 1973, we described an outline of the second largest concentration of familial amyloid polyneuropathy (FAP) cases which we discovered. We reported some tentative results of DMSO treatment in 18 cases. In this paper, we are presenting the effects of DMSO administration to patients with primary and familial amyloidosis from both clinical and biochemical viewpoints and in vitro effects of DMSO on extracted amyloid fibril proteins. This article is from 'Conference on Biological Actions and Medical Applications of Dimethyl Sulfoxide (DMSO), 15-17 September 1982,' AD-A133 175. p52-66.