Treatment of Cerebral Infarction with Dimethyl Sulfoxide in the Mongolian Gerbil

Dimethyl sulfoxide (DMSO) has been reported to have beneficial effects in the treatment of central nervous system trauma, possibly due to its reported anti-inflammatory, antiedemic, anticoagulate, diuretic, hypothermic, vasodilatory, and respiratory stimulatory effects as well as an ability to corre...

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Bibliographic Details
Main Author: McGraw,C. Patrick
Format: Report
Language:English
Subjects:
Brain
Chemotherapy
Component reports
Dimethyl sulfoxide
Edema
Infarction
Inflammation
Methyl sulfoxide
Physiological effects
Rhesus monkeys
Symposia
Trauma
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Summary:Dimethyl sulfoxide (DMSO) has been reported to have beneficial effects in the treatment of central nervous system trauma, possibly due to its reported anti-inflammatory, antiedemic, anticoagulate, diuretic, hypothermic, vasodilatory, and respiratory stimulatory effects as well as an ability to correct membrane instability and penetrate the blood-brain barrier. In this paper we discussed these properties, and how they may be of benefit in ischemic cerebral infarction and elevated intracranial pressure. We also described a study we performed to determine if treatment with DMSO would decrease the morbidity and mortality from experimental cerebral infarction. This article is from 'Conference on Biological Actions and Medical Applications of Dimethyl Sulfoxide (DMSO), 15-17 September 1982,' AD-A133 175. p278-285.