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Risk of Ischemic Heart Disease in Patients with Sjögren′s Syndrome

Abstract Background Ischemic heart disease (IHD) has emerged as a major cause of morbidity and mortality in patients with autoimmune conditions such as systemic lupus erythematosus and rheumatoid arthritis, but the risk of IHD in Sjögren′s Syndrome (SjS) is unknown. To fill this knowledge gap, we es...

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Published in:The American journal of the medical sciences 2017
Main Authors: Luni, Faraz Khan, MD, Malik, Sonia Ali, MD, Khan, Abdur Rahman, MD, Riaz, Haris, MD, Singh, Hemindermeet, MD, Federman, Douglas, MD, Kanjwal, Yusuf, MD, Dasa, Osama, MD, Khuder, Sadik, PhD, Kabour, Ameer, MD
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Language:English
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Summary:Abstract Background Ischemic heart disease (IHD) has emerged as a major cause of morbidity and mortality in patients with autoimmune conditions such as systemic lupus erythematosus and rheumatoid arthritis, but the risk of IHD in Sjögren′s Syndrome (SjS) is unknown. To fill this knowledge gap, we estimated the prevalence and risk of IHD with SjS compared to controls from the general population using Healthcare Cost and Utilization Project (HCUP) National Inpatient Sample 2011 database. Methods The HCUP administrative longitudinal database contains encounter-level information on inpatient stays, emergency department visits and ambulatory surgery in all the United States hospitals. We conducted a cross sectional study among the inpatient population diagnosed with SjS and matched 1:4 with controls for age, gender and hospital region. Odds ratio (OR) for IHD was calculated as cases compared to controls. The contribution of various risk factors to IHD were also evaluated by logistic regression. Results Analysis demonstrated that 7,154 of 13,086 cases (54.7%) of SjS had IHD compared to 27,367 of 52,448 controls (52.2%). The adjusted OR for IHD in those with SjS is 0.898 (95% CI of 0.844–0.955). Patients with Sjs were significantly more likely to have hypertension, diabetes, apnea and lipid disorders. Conclusion To our knowledge, this is the largest population-based study investigating the risk of IHD in patients with SjS. We found a modest though statistically significant decrease in the risk of IHD in SjS compared to controls.
ISSN:0002-9629
DOI:10.1016/j.amjms.2017.05.001