Bone Grafts and Bone Graft Substitutes in Orthopaedic Trauma Surgery

➤ Osteoinduction is a process that supports the mitogenesis of undifferentiated mesenchymal cells, leading to the formation of osteoprogenitor cells that form new bone. ➤ The human skeleton has the ability to regenerate itself as part of the repair process. ➤ Recombinant bone morphogenetic protein h...

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Bibliographic Details
Published in:Journal of bone and joint surgery. American volume 2007, Vol.89 (3), p.649-658
Main Authors: De Long, William G., MD, Einhorn, Thomas A., MD, Koval, Kenneth, MD, McKee, Michael, MD, Smith, Wade, MD, Sanders, Roy, MD, Watson, Tracy, MD
Format: Article
Language:English
Subjects:
Orthopedics
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Summary:➤ Osteoinduction is a process that supports the mitogenesis of undifferentiated mesenchymal cells, leading to the formation of osteoprogenitor cells that form new bone. ➤ The human skeleton has the ability to regenerate itself as part of the repair process. ➤ Recombinant bone morphogenetic protein has osteoinductive properties, the effectiveness of which is supported by Level-I evidence from current literature sources. ➤ Osteoconduction is a property of a matrix that supports the attachment of bone-forming cells for subsequent bone formation. ➤ Osteogenic property is a relatively new term that can be defined as the generation of bone from bone-forming cells.
ISSN:0021-9355
DOI:10.1016/S0021-9355(07)73562-2