Fructose malabsorption in people with and without gout a case controlled study

Abstract Background Higher fructose intake has been associated with hyperuricaemia and gout. Some individuals malabsorb fructose in the small intestine. The aims of this study were to determine the rate of fructose malabsorption and the effects of gout and fructose malabsorption on serum urate in pe...

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Bibliographic Details
Published in:Seminars in arthritis and rheumatism 2017
Main Authors: Batt, Caitlin, Fanning, Niamh, Drake, Jill, Frampton, Christopher, Gearry, Richard B, Stamp, Lisa K
Format: Article
Language:English
Subjects:
Rheumatology
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Summary:Abstract Background Higher fructose intake has been associated with hyperuricaemia and gout. Some individuals malabsorb fructose in the small intestine. The aims of this study were to determine the rate of fructose malabsorption and the effects of gout and fructose malabsorption on serum urate in people with and without gout. Methods One-hundred people with gout (cases) were age and gender matched with one control without gout. After a low fructose diet, fructose malabsorption was measured using a hydrogen or methane breath test with a 35gm fructose load. In a subgroup of 35 cases and 35 controls, serum urate response to the fructose load over 240 minutes was measured. Results There was no significant difference in the rate of fructose malabsorption between cases and controls (48% vs. 52%; p=0.67). Cases had a significantly lower mean (SEM) serum urate iAUC0–240 compared to controls 0.97 (0.56) vs. 4.78 (0.55); p
ISSN:0049-0172
DOI:10.1016/j.semarthrit.2017.03.018