Targeting HSF1reduces Apg-1 expression and enhances BTZ-mediated MM Cell apoptosis

Highlights • Finding a new approach to treatment of multiple myeloma. • The mechanism relies on administration of BTZ in combination with either Apg-1 knockdown or HSF1 inhibitor. • The approach is a great value to improve the chemo-resistance in multiple myeloma therapeutic effects.

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Bibliographic Details
Published in:Leukemia research 2017
Main Authors: Zhu, Xinyu, Wang, Qiru, Ding, Linlin, Zhong, Fei, Ou, Yangyu, Xu, Xiaohong, Wang, Yuchan
Format: Article
Language:English
Subjects:
Hematology, Oncology and Palliative Medicine
Online Access:Get full text
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Summary:Highlights • Finding a new approach to treatment of multiple myeloma. • The mechanism relies on administration of BTZ in combination with either Apg-1 knockdown or HSF1 inhibitor. • The approach is a great value to improve the chemo-resistance in multiple myeloma therapeutic effects.
ISSN:0145-2126
DOI:10.1016/j.leukres.2017.05.003