Clinical safety and effectiveness of biphasic insulin aspart 30 in type 2 diabetes patients switched from biphasic human insulin 30: Results from the Indonesian cohort of the A1 chieve study

• Published in: Diabetes research and clinical practice 2013, Vol.100, p.S41-S46
• Main Authors: Soewondo, Pradana, Lindarto, Dharma, Wibisono, Sony, Renaldi, Olly, Dalem-Pemayun, Tjokorda Gde
• Format: Article
• Language: English
• Subjects: Endocrinology & Metabolism
• ISSN: 0168-8227
• DOI: 10.1016/S0168-8227(13)70009-3

Abstract Aim To evaluate the safety and effectiveness of biphasic insulin aspart 30 (BIAsp 30) in Indonesian type 2 diabetes patients switched from biphasic human insulin 30 (BHI 30) as a sub-analysis of the A1 chieve study. Methods Clinical safety and effectiveness over 24 weeks was evaluated in Indonesian patients who switched from BHI 30 to BIAsp 30 at the discretion of their physician. Results A total of 244 patients with mean age ± SD 55.6±9.5 years, BMI 24.6±3.8kg/m2 , and mean diabetes duration 7.8±5.7 years were included. The mean pre-study BHI 30 dose was 0.56±0.25 IU/kg and the baseline BIAsp 30 dose was 0.60±0.26U/kg titrated up to 0.65±0.25 U/kg by Week 24. No serious adverse drug reactions were reported throughout the study. Overall hypoglycaemia decreased from 2.18 to 0.06 events/patient-year with a significant decrease in the proportion of patients affected (p < 0.0001). No nocturnal or major hypoglycaemia was reported at Week 24. HbA1c improved from 8.8±1.2% at baseline to 7.3±0.8% at Week 24. A total of 45 patients achieved HbA1c