Temporal changes of EGFR mutations and T790 M levels in tumor and plasma DNA following AZD9291 treatment

Highlights • Droplet digital PCR of cell free DNA (cf DNA) enables monitoring of patients on AZD9291 treatment. • Temporal monitoring of cfDNA EGFR T790 M and activating EGFR mutational load evaluates response. • Monitoring levels of the initial mutation may facilitate more reliable detection of pro...

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Bibliographic Details
Published in:Lung cancer (Amsterdam, Netherlands) Netherlands), 2016
Main Authors: Chia, Puey Ling, Do, Hongdo, Morey, Adrienne, Mitchell, Paul, Dobrovic, Alexander, John, Thomas
Format: Article
Language:English
Subjects:
Hematology, Oncology and Palliative Medicine
Pulmonary/Respiratory
Online Access:Get full text
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Summary:Highlights • Droplet digital PCR of cell free DNA (cf DNA) enables monitoring of patients on AZD9291 treatment. • Temporal monitoring of cfDNA EGFR T790 M and activating EGFR mutational load evaluates response. • Monitoring levels of the initial mutation may facilitate more reliable detection of progression.
ISSN:0169-5002
DOI:10.1016/j.lungcan.2016.05.003