Near-infrared optical guided surgery of highly infiltrative fibrosarcomas in cats using an anti-αv ß3 integrin molecular probe

Abstract We investigated how near-infrared imaging could improve highly infiltrative spontaneous fibrosarcoma surgery in 12 cats in a clinical veterinary phase. We used an RGD-based nanoprobe at different doses and times before surgery and a portable clinical grade imaging system. All tumours were l...

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Bibliographic Details
Published in:Cancer letters 2012, Vol.334 (2), p.188-195
Main Authors: Wenk, Christiane H.F, Ponce, Frédérique, Guillermet, Stéphanie, Tenaud, Corinne, Boturyn, Didier, Dumy, Pascal, Watrelot-Virieux, Dorothée, Carozzo, Claude, Josserand, Véronique, Coll, Jean-Luc
Format: Article
Language:English
Subjects:
Hematology, Oncology and Palliative Medicine
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Summary:Abstract We investigated how near-infrared imaging could improve highly infiltrative spontaneous fibrosarcoma surgery in 12 cats in a clinical veterinary phase. We used an RGD-based nanoprobe at different doses and times before surgery and a portable clinical grade imaging system. All tumours were labelled by the tracer and had an overall tumour-to-healthy tissue ratio of 14 ± 1 during surgery. No false negatives were found, and the percentage of tumour cells was linearly correlated with the fluorescence intensity. All cats recovered well and were submitted to long-term follow-up that is currently on-going 1 year after the beginning of the study.
ISSN:0304-3835
DOI:10.1016/j.canlet.2012.10.041