Gephyrin plays a key role in BDNF-dependent regulation of amygdala surface GABAA Rs

Highlights • GABAA receptor α1 and γ2 subunits are associated with Gephyrin in mouse amygdala. • Short BDNF treatment or suppression of Gephyrin protein sequesters surface GABAα1. • Short BDNF treatment decreases, whereas longer exposure increases Gephyrin levels. • Total Gephyrin is reduced, but Ge...

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Bibliographic Details
Published in:Neuroscience 2013, Vol.255, p.33-44
Main Authors: Mou, L, Dias, B.G, Gosnell, H, Ressler, K.J
Format: Article
Language:English
Subjects:
Neurology
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Summary:Highlights • GABAA receptor α1 and γ2 subunits are associated with Gephyrin in mouse amygdala. • Short BDNF treatment or suppression of Gephyrin protein sequesters surface GABAα1. • Short BDNF treatment decreases, whereas longer exposure increases Gephyrin levels. • Total Gephyrin is reduced, but Gephryin-GABAα1 complexes are increased with BDNF. • Gephyrin may be critical in BDNF-dependent GABAA regulation in the amygdala.
ISSN:0306-4522
DOI:10.1016/j.neuroscience.2013.09.051