Blood-Brain Barrier Disruption was less under Isoflurane than Pentobarbital Anesthesia via a PI3 K/Akt Pathway in Early Cerebral Ischemia

Highlights • Early focal cerebral ischemia increased blood-brain barrier (BBB) disruption. • Degree of BBB disruption was lower under isoflurane than pentobarbital anesthesia. • Baseline BBB permeability was higher under pentobarbital in non-ischemic area. • PI3 K/Akt inhibition aggravated BBB disru...

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Bibliographic Details
Published in:Brain research bulletin 2017
Main Authors: Chi, Oak Z, Mellender, Scott J, Kiss, Geza K, Liu, Xia, Weiss, Harvey R
Format: Article
Language:English
Subjects:
Neurology
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Summary:Highlights • Early focal cerebral ischemia increased blood-brain barrier (BBB) disruption. • Degree of BBB disruption was lower under isoflurane than pentobarbital anesthesia. • Baseline BBB permeability was higher under pentobarbital in non-ischemic area. • PI3 K/Akt inhibition aggravated BBB disruption only under isoflurane in ischemia.
ISSN:0361-9230
DOI:10.1016/j.brainresbull.2017.02.007