Repeatability of CT-based anthropomorphic measurements of frailty in patients with pulmonary fibrosis undergoing lung transplantation

• Published in: Current problems in diagnostic radiology 2016
• Main Authors: McClellan, Taylor, MD, Allen, Brian C., MD, Kappus, Matthew, MD, Bhatti, Lubna, MBBS, Dafalla, Randa A., MD, Snyder, Laurie D., MD, Bashir, Mustafa R
• Format: Article
• Language: English
• Subjects: Internal Medicine; Radiology
• ISSN: 0363-0188
• DOI: 10.1067/j.cpradiol.2016.12.009

Purpose To determine inter- and intra-reader repeatability and correlations between measurements of CT based anthropomorphic measurements in patients with pulmonary fibrosis undergoing lung transplantation. Methods This was an IRB approved, HIPAA compliant retrospective study of 23 randomly selected subjects (19 male and 4 female; median age: 69 years, range: 66–77 years) with idiopathic pulmonary fibrosis undergoing pulmonary transplantation, who had also undergone preoperative thoraco-abdominal CT. Five readers of varying imaging experience independently performed the following cross-sectional area measurements at the inferior endplate of the L3 vertebral body: right and left psoas muscles, right and left paraspinal muscles, total abdominal musculature, visceral and subcutaneous fat. The following measurements were obtained at the inferior endplate of T6: right and left paraspinal muscles with and without including the trapezius muscles and subcutaneous fat. Three readers repeated all measurements to assess intra-reader repeatability. Results Intra-reader repeatability was nearly perfect (ICC=0.99, p