Repeated Loss of Consciousness in a Young Woman: Smad3 Mutation Underlying Spontaneous Coronary Artery Dissection

Abstract Spontaneous coronary artery dissection (SCAD) is an infrequent etiology of acute coronary syndrome (ACS) and is often underdiagnosed. Intramural hematoma is the most frequent angiographic presentation, a challenging diagnosis that may require intravascular imaging techniques to confirm it a...

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Bibliographic Details
Published in:Canadian journal of cardiology 2016
Main Authors: Garcia-Bermúdez, Míriam, MD, MsC, Moustafa, Abdel-Hakim, MD, Tizón-Marcos, Helena, MD, MsC
Format: Article
Language:English
Subjects:
Cardiovascular
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Summary:Abstract Spontaneous coronary artery dissection (SCAD) is an infrequent etiology of acute coronary syndrome (ACS) and is often underdiagnosed. Intramural hematoma is the most frequent angiographic presentation, a challenging diagnosis that may require intravascular imaging techniques to confirm it and to guide treatment. It affects mostly young women without coronary risk factors and is usually associated with fibromuscular dysplasia. SCAD has an underlying disease in 80% of patients. SMAD3 mutation has been linked to aneurysm-osteoarthritis syndrome and has been identified as a cause of familial thoracic aortic aneurysm and dissection. The first reported case of SMAD3 mutation underlying SCAD is described here.
ISSN:0828-282X
DOI:10.1016/j.cjca.2016.09.004