Ubá mango juice intake decreases adiposity and inflammation in high-fat diet-induced obese Wistar rats

• Published in: Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2016
• Main Authors: Natal, Dorina Isabel Gomes, M.Sc, de Castro Moreira, Maria Eliza, Ph.D, Milião, Mariana Soares, Graduate, dos Anjos Benjamin, Laércio, Ph.D, de Souza Dantas, Maria Inês, Ph.D, Rocha Ribeiro, Sônia Machado, Ph.D, Duarte Martino, Hércia Stampini, Ph.D
• Format: Article
• Language: English
• Subjects: Gastroenterology and Hepatology
• ISSN: 0899-9007
• DOI: 10.1016/j.nut.2016.02.008

Abstract Objective The aim of this study was to determine the effect of Ubá mango juices with and without peel extract in the adiposity and inflammation modulation in high-fat diet-induced obese Wistar rats. Research Methods & Procedures It was analyzed the total phenolic and antioxidant activity of the juices in different storage conditions. The biometry and biochemical parameters were evaluated in four experimental groups: normal control (AIN-93M), obese control (HFD), a group with obese rats plus control Ubá mango juice (MHFD) and other with antioxidant enriched Ubá mango juice (HMHFD). Also PPAR-γ, LPL and FAS expression, pro and anti-inflammatory cytokines, TNF-α and IL-10, as well as histomorphology of the epididymal adipose tissue were determined. Results The Ubá mango juices had high content of phenolic compounds and high antioxidant activity with no change due to storage time. HFD promoted the highest weight gain per gram of diet intake due to caloric density and mango juices reversed the high fat diet effect; the weight gain, visceral fat, body mass index and adiposity became similar to AIN-93M. MHFD and HMHFD showed antioxidant and anti-inflammatory effects by increasing HDL-cholesterol fraction, PPAR-γ, LPL and decreasing blood glucose, total cholesterol, ALT, FAS and TNF-α. In addition, the epididymal adipose tissue histology confirmed the juices’ effect to reduce the adipocyte hypertrophy. Conclusions Thus, the results showed that Ubá mango has potential as a functional food capable of reducing metabolic risk of obesity associated with adiposity and inflammation.