Association of Serum Cystatin C with Acute Ischemic Stroke

• Published in: Journal of stroke and cerebrovascular diseases 2014
• Main Authors: Danthala, Madhav, MD, Srinivasa, S.V., MD, Venkataswamy, Lakshmaiah, MD, Gowda, Srirama, MD
• Format: Article
• Language: English
• Subjects: Acute ischemic stroke; Cardiovascular; Cystatin C; Neurology; NIH Stroke scale
• ISSN: 1052-3057; 1532-8511
• DOI: 10.1016/j.jstrokecerebrovasdis.2013.12.024

Background The attractiveness of cystatin C as a biomarker for acute ischemic stroke is obvious in the background of accumulating evidence indicating a link between vascular disease of the kidney and brain. We investigated the association of serum cystatin C levels with first onset acute ischemic stroke and the correlation of serum cystatin C levels with severity of acute ischemic stroke as assessed by National Institutes of Health stroke scale score. The present study is a comparative study of 50 patients presenting with first onset acute ischemic stroke and 50 matched healthy controls. Materials and Methods Data were collected from 50 patients of first onset acute ischemic stroke, aged more than 45 years, presenting within 72 hours after the onset, by interview, history, clinical examination, neuroimaging, and other investigations and 50 healthy age- and sex-matched controls.The statistical software, namely, SAS 9.2, SPSS 15.0, Stata 10.1, MedCalc 9.0.1, Systat 12.0, and R environment ver. 2.11.1 were used for the analysis of the data, and Microsoft word and Excel were used to generate graphs and tables. Results Serum cystatin C levels were significantly raised in 66% (n = 33) patients of acute ischemic stroke compared with controls 18% (n = 9), with a P