Recent Advances and Prospects for Multi-Modality Therapy in Pancreatic Cancer

Abstract The outcomes for treatment of pancreatic cancer have not improved dramatically in many decades. However, recent promising results with combination chemotherapy regimens for metastatic disease increase optimism for future treatments. With greater control of overt or occult metastatic disease...

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Bibliographic Details
Published in:Seminars in radiation oncology 2016
Main Authors: Chadha, Awalpreet S, Khoo, Allison, Aliru, Maureen L, Arora, Harpreet K, Gunther, Jillian R, Krishnan, Sunil
Format: Article
Language:English
Subjects:
Hematology, Oncology and Palliative Medicine
Radiology
Online Access:Get full text
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Summary:Abstract The outcomes for treatment of pancreatic cancer have not improved dramatically in many decades. However, recent promising results with combination chemotherapy regimens for metastatic disease increase optimism for future treatments. With greater control of overt or occult metastatic disease, there will likely be an expanding role for local treatment modalities, especially given that nearly a third of pancreatic cancer patients have locally destructive disease without distant metastatic disease at time of death. Technical advances have allowed for the safe delivery of dose-escalated radiation therapy, which can then be combined with chemotherapy, targeted agents, immunotherapy, and nanoparticulate drug delivery techniques to produce novel and improved synergistic effects. Here we discuss recent advances and future directions for multimodality therapy in pancreatic cancer.
ISSN:1053-4296
DOI:10.1016/j.semradonc.2016.05.002