Predictors of large for gestational age birth weight among pregnant women with type 1 and type 2 diabetes: A retrospective cohort study

ObjectiveTo compare the effects of risk factors for large for gestational age (LGA) birth weight between women with type 1 (TIDM) and type 2 diabetes (T2DM). MethodsA retrospective cohort study was conducted for women with T1DM (n=152) and T2DM (n=255) attending a Diabetes/Pregnancy Clinic 2009 to 2...

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Bibliographic Details
Published in:Canadian journal of diabetes 2019
Main Authors: Alexander, Lisa D, Tomlinson, George, Feig, Denice S
Format: Article
Language:English
Subjects:
Endocrinology and Metabolism
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Summary:ObjectiveTo compare the effects of risk factors for large for gestational age (LGA) birth weight between women with type 1 (TIDM) and type 2 diabetes (T2DM). MethodsA retrospective cohort study was conducted for women with T1DM (n=152) and T2DM (n=255) attending a Diabetes/Pregnancy Clinic 2009 to 2016. Multiple logistic regression analysis was used to identify variables associated with LGA. ResultsLGA was significantly higher in T1DM (39%) than T2DM (17%) (p< 0.001). Among T1DM, there was a non-significant association between LGA and CSII (OR=1.17, 95%CI=0.99-1.39, p=0.06) and excess maternal weight gain (T1DM OR=1.19, 95%CI=0.99-1.43, p=0.069;). In T2DM there was an association between LGA and hemoglobin A1C at delivery (T2DM OR=1.10, 95%CI=1.02-1.19, p=0.01). DiscussionIn the study population, glycemic control at delivery was predictive of LGA in women with T2DM and there was a trend toward an association of maternal weight gain and CSII with LGA in T1DM. ConclusionsFurther study is warranted to better guide targeted interventions to reduce high rates of LGA in T1DM/T2DM.
ISSN:1499-2671
DOI:10.1016/j.jcjd.2019.08.015