Acute myeloid leukemia presenting with Sweet’s syndrome: A case report and review of the literature

Abstract Sweet's Syndrome (SS), or acute febrile neutrophilic dermatosis, is a rare skin disorder characterized by painful cutaneous nodules and neutrophilic infiltrate in the dermis, which is usually accompanied by fever and other inflammatory reactions. SS may be idiopathic, malignancy-associ...

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Bibliographic Details
Published in:Pediatrics and neonatology 2016
Main Authors: Chen, Shu-Huey, M.D, Kuo, Yung-Ting, M.D, Liu, Yen-Lin, M.D, Chen, Bo-Jung, Lu, Yuan-Chieh, Miser, James S., Dr
Format: Article
Language:English
Subjects:
Internal Medicine
Pediatrics
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Summary:Abstract Sweet's Syndrome (SS), or acute febrile neutrophilic dermatosis, is a rare skin disorder characterized by painful cutaneous nodules and neutrophilic infiltrate in the dermis, which is usually accompanied by fever and other inflammatory reactions. SS may be idiopathic, malignancy-associated, or drug-induced. We present the case of a 15-year-old girl with acute myeloid leukemia, whose initial presentation was SS. After only partial response to antibiotics and an antihistamine, a skin biopsy had led to the diagnosis of SS and the patient had later developed AML. After induction chemotherapy with idarubicin and arabinoside, the patient had successfully achieved remission of the AML as well as the SS. In children, SS is very rare and mimics skin and soft tissue infections. However, SS can also be an early sign of childhood cancer, especially hematologic malignancies. Physicians should be aware of SS when the patient has typical skin lesions and keep a high index of suspicion to search for underlying malignancies.
ISSN:1875-9572
DOI:10.1016/j.pedneo.2016.05.002