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The Metabolic Syndrome in long-term survivors of Haematopoietic Stem Cell Transplantation

Abstract Since its introduction more than fifty years ago, haematopoietic stem cell transplantation (HSCT) has transformed from an inescapably fatal procedure to one where cure from malignant and other non-malignant haematological diseases is becoming increasingly common. Nevertheless, longevity is...

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Bibliographic Details
Published in:Clinical lymphoma, myeloma and leukemia myeloma and leukemia, 2017
Main Authors: Ragbourne, S.C., BSc, MB BS, Crook, M.A., BSc, MB BS, MA, PhD, FRCPath, FRCPI, FRCP
Format: Article
Language:English
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Summary:Abstract Since its introduction more than fifty years ago, haematopoietic stem cell transplantation (HSCT) has transformed from an inescapably fatal procedure to one where cure from malignant and other non-malignant haematological diseases is becoming increasingly common. Nevertheless, longevity is not entirely restored. New causes of mortality have emerged; of particular importance is that of increased cardiovascular disease (CVD), related to metabolic syndrome (MS) and its components. Controversy exists over whether the metabolic abnormalities induced are a direct effect of HSCT itself or a consequence of other therapies involved. Analysis of the mechanisms which promote the changes in metabolic components will give insight into future HSCT therapy and also CVD pathogenesis and prevention.
ISSN:2152-2650
DOI:10.1016/j.clml.2017.05.004