Characterization of prostate cancer using T2 mapping at 3 T: A multi-scanner study

• Published in: Diagnostic and interventional imaging 2015-04, Vol.96 (4), p.365-372
• Main Authors: Hoang Dinh, A, Souchon, R, Melodelima, C, Bratan, F, Mège-Lechevallier, F, Colombel, M, Rouvière, O
• Format: Article
• Language: English
• Subjects: Radiology
• ISSN: 2211-5684; 2211-5684
• DOI: 10.1016/j.diii.2014.11.016

Abstract Rationale and objectives To assess the prostate T2 value as a predictor of malignancy on two different 3 T scanners. Patients and methods Eighty-three pre-prostatectomy multiparametric MRIs were retrospectively evaluated [67 obtained on a General Electric MRI (scanner 1) and 16 on a Philips MRI (scanner 2)]. After correlation with prostatectomy specimens, readers measured the T2 value of regions-of-interest categorized as “cancers”, “false positive lesions”, or “normal tissue”. Results On scanner 1, in PZ, cancers had significantly lower T2 values than false positive lesions ( P = 0.02) and normal tissue ( P = 2 × 10−9 ). Gleason ≥ 6 cancers had similar T2 values than false positive lesions and significantly higher T2 values than Gleason ≥ 7 cancers ( P = 0.009). T2 values corresponding to a 25% and 75% risk of Gleason ≥ 7 malignancy were respectively 132 ms (95% CI: 129–135 ms) and 77 ms (95% CI: 74–81 ms). In TZ, cancers had significantly lower T2 values than normal tissue ( P = 0.008), but not than false positive findings. Mean T2 values measured on scanner 2 were not significantly different than those measured on scanner 1 for all tissue classes. Conclusion All tested tissue classes had similar mean T2 values on both scanners. In PZ, the T2 value was a significant predictor of Gleason ≥ 7 cancers.