Intravenous Bisphosphonates Therapy does not Thicken Cementum or Change Periodontal Ligament of Cancer Patients

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology oral medicine, oral pathology and oral radiology, 2017
• Main Authors: Paglioni, Mariana de Pauli, DDS, MSc, Gomes da Silva, Wagner, DDS, MSc, Pereira, Juliana, MD, MSc, Migliorati, César Augusto, DDS, MSc, PhD, Lopes, Marcio Ajudarte, DDS, MSc, PhD, de Almeida, Oslei Paes, DDS, MSc, PhD, Goes, Mario Fernando, DDS, MSc, PhD, Ribeiro, Ana Carolina Prado, DDS, MSc, PhD, Brandão, Thais Bianca, DDS, MSc, Santos-Silva, Alan Roger, DDS, MSc, PhD
• Format: Article
• Language: English
• Subjects: Surgery
• ISSN: 2212-4403
• DOI: 10.1016/j.oooo.2017.02.008

Abstract Objective To test the hypothesis that intravenous (IV) bisphosphonates (BPs) therapy thicken or alter the micromorphology of cementum and periodontal ligament (PL) in cancer patients. Study design 32 teeth extracted from 24 cancer patients and separated in test (n=16; patients who have undergone IV BPs) and control (n=16; patients naive to BPs) groups were studied. Cementum thickness was measured in 3 different areas of the dental root through polarized light microscopy and micromorphology of cementum. PL was accessed by optical light microscopy and the immunohistochemical expression of periostin. Results No significant difference was detected in cementum thickness (apical: p=0.06; medium: p=0.16; cervical: p=0.18) between groups. The numbers of fibroblasts (p=0.56), incremental lines of cementum (p=0.51) and the immunohistochemical patterns of periostin expression in PL (p=0.68) did no differ between groups. Conclusion IV BPs therapy does not thicken cementum or change the micromorphology of LP.