Loading…

1,25-Dihydroxyvitamin D 3 Regulation of Myocardial Growth and c-myc Levels in the Rat Heart

In this report we demonstrate that rats maintained on a calcium supplemented vitamin D 3-deficient diet for nine weeks showed an increase in heart to body weight ratio. Morphometric analysis indicated that vitamin D 3 deficiency produced cardiac myocytes that were smaller yet more numerous, indicati...

Full description

Saved in:
Bibliographic Details
Published in:Biochemical and biophysical research communications 1995-08, Vol.213 (1), p.59-65
Main Authors: Oconnell, T.D., Simpson, R.U.
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this report we demonstrate that rats maintained on a calcium supplemented vitamin D 3-deficient diet for nine weeks showed an increase in heart to body weight ratio. Morphometric analysis indicated that vitamin D 3 deficiency produced cardiac myocytes that were smaller yet more numerous, indicating hyperplasia, Western blot analysis showed that vitamin D 3 deficiency also resulted in increased c-myc protein levels in the hearts of vitamin D 3-deficient rats. Furthermore, 1,25-dihydroxyvitamin D 3 reduced c-myc protein levels in primary cultures of ventricular myocytes from neonatal rat hearts. Our data suggest a possible relationship between myocyte hyperplasia and increased c-myc levels in the vitamin D 3-deficient rat heart.
ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.1995.2098