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1,25-Dihydroxyvitamin D 3 Regulation of Myocardial Growth and c-myc Levels in the Rat Heart
In this report we demonstrate that rats maintained on a calcium supplemented vitamin D 3-deficient diet for nine weeks showed an increase in heart to body weight ratio. Morphometric analysis indicated that vitamin D 3 deficiency produced cardiac myocytes that were smaller yet more numerous, indicati...
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Published in: | Biochemical and biophysical research communications 1995-08, Vol.213 (1), p.59-65 |
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Main Authors: | , |
Format: | Article |
Language: | English |
Online Access: | Get full text |
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Summary: | In this report we demonstrate that rats maintained on a calcium supplemented vitamin D
3-deficient diet for nine weeks showed an increase in heart to body weight ratio. Morphometric analysis indicated that vitamin D
3 deficiency produced cardiac myocytes that were smaller yet more numerous, indicating hyperplasia, Western blot analysis showed that vitamin D
3 deficiency also resulted in increased
c-myc protein levels in the hearts of vitamin D
3-deficient rats. Furthermore, 1,25-dihydroxyvitamin D
3 reduced
c-myc protein levels in primary cultures of ventricular myocytes from neonatal rat hearts. Our data suggest a possible relationship between myocyte hyperplasia and increased c-myc levels in the vitamin D
3-deficient rat heart. |
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ISSN: | 0006-291X 1090-2104 |
DOI: | 10.1006/bbrc.1995.2098 |