Isolation and Characterization of a New Member of the HumanLy6Gene Family(LY6H)

TheLy6family of genes encodes glycosylphosphatidylinositol-anchored cell surface glycoproteins expressed on various types of cells. Intriguing patterns of expression ofLy6genes on specific subpopulations of lymphoid and myeloid cells suggest that Ly6 molecules may be involved in the development and...

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Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 1998-11, Vol.53 (3), p.365-368
Main Authors: Horie, Masato, Okutomi, Keiichi, Taniguchi, Yoshihiro, Ohbuchi, Yutaka, Suzuki, Mikio, Takahashi, Ei-ichi
Format: Article
Language:English
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Summary:TheLy6family of genes encodes glycosylphosphatidylinositol-anchored cell surface glycoproteins expressed on various types of cells. Intriguing patterns of expression ofLy6genes on specific subpopulations of lymphoid and myeloid cells suggest that Ly6 molecules may be involved in the development and homeostasis of hematopoietic cells. We have isolated a new member of the humanLy6gene family,LY6H,from a human fetal brain cDNA library. Fluorescencein situhybridization and radiation hybrid analyses assignedLY6Hto chromosome 8, where other members of theLy6gene family are also located. Northern analysis revealed thatLY6His highly expressed in particular subdivisions of human brain and also in MOLT-3 and -4 acute lymphoblastic leukemia cells. These data suggest that LY6H may play a role(s) in both the central nervous system and the immune system.
ISSN:0888-7543
1089-8646
DOI:10.1006/geno.1998.5462