Cytotoxic and antioxidant activities and phytochemical analysis of Smilax excelsa L. and Aegopodiumpodagraria L

New curative and preventative approaches with high therapeutic efficacy and minimal side effects are needed for many forms of cancer. Therefore, the current study aimed to assess the cytotoxic and antioxidant capacity of Smilax excelsa and Aegopodium podagraria, which are consumed on a daily diet in...

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Bibliographic Details
Published in:Food bioscience 2023-04, Vol.52, Article 102359
Main Authors: Yılmaz Sarıaltın, Sezen, Çiçek Polat, Derya, Yalçın, Can Özgür
Format: Article
Language:English
Subjects:
Aegopodium podagraria
Cytotoxicity
Phytochemistry
Smilax excelsa, antioxidant
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Summary:New curative and preventative approaches with high therapeutic efficacy and minimal side effects are needed for many forms of cancer. Therefore, the current study aimed to assess the cytotoxic and antioxidant capacity of Smilax excelsa and Aegopodium podagraria, which are consumed on a daily diet in the Black Sea region of Turkiye, as well as their phytochemical composition to pinpoint the compounds responsible for these activities. The effects of the treatments on human prostate (PC3), colorectal (HCT116), and lung (A549) carcinoma cell survival and free radical scavenging potentials were investigated. Total phenolic and flavonoid contents and significant phenolic compounds were detected and quantified by HPLC. The extracts reduced cell viability in all cancer cells in a dose-dependent manner, while the most potent cytotoxic effects were noted on PC3 cells. S. excelsa inhibited cell growth on PC3 cells at both lower and higher concentrations (50–1000 μg/mL) compared with the control (p 
ISSN:2212-4292
2212-4306
DOI:10.1016/j.fbio.2023.102359