Hypoglycemic effect of Trichosanthis Radix resistant starch combined with rutin on diabetic mice

In this study, the hypoglycemic effects and mechanisms of different intervention substances (Trichosanthis Radix resistant starch, rutin, Trichosanthis Radix resistant starch-rutin complex) were investigated on C57BL/6 diabetic mice induced by high glucose-fat diet combined with streptozotocin. The...

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Bibliographic Details
Published in:Food bioscience 2025-01, Vol.63, p.105609, Article 105609
Main Authors: Hu, Jiejie, Huang, Rui, Guo, Jingchong, Li, Jiaying, Yang, Xiaoping, Deng, Xiangrui, Huang, Ganhui, Gu, Zhenyu
Format: Article
Language:English
Subjects:
Rutin
Trichosanthis Radix resistant starch
Type 2 diabetes
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Summary:In this study, the hypoglycemic effects and mechanisms of different intervention substances (Trichosanthis Radix resistant starch, rutin, Trichosanthis Radix resistant starch-rutin complex) were investigated on C57BL/6 diabetic mice induced by high glucose-fat diet combined with streptozotocin. The results indicate that the Trichosanthis Radix resistant starch (T-RS) group showed superior effect compared to the rutin group in terms of increasing body weight, lowering blood glucose, regulating oral glucose tolerance, reducing insulin levels, promoting glycogen and lipid metabolism; while rutin group exhibited a better inhibitory effect on oxidative stress related to diabetes. Compared to the rutin group and T-RS group, the Trichosanthis Radix resistant starch -rutin complex (RuT-RS) group showed more significant regulatory effects on liver glycogen, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and glutathione peroxidase (P 
ISSN:2212-4292
DOI:10.1016/j.fbio.2024.105609