Organotin(IV) complexes anchored on the magnetic UiO-66-NH2 metal–organic framework: Synthesis and evaluation of cytotoxicity

• Published in: Inorganic chemistry communications 2025-02, Vol.172, p.113686, Article 113686
• Main Authors: Latifisaber, Hamideh, Sedaghat, Tahereh, Hoveizi, Elham
• Format: Article
• Language: English
• Subjects: Cytotoxicity; Hydrazone; Magnetic nanocomposite; Metal-organic framework; Organotin(IV)
• ISSN: 1387-7003
• DOI: 10.1016/j.inoche.2024.113686

[Display omitted] •Organotin(IV) complexes were immobalized on functionalized Fe3O4@UiO-66-NH2 by post-synthetic modification.•MOF-based magnetic nanocomposites carrying organotin(IV) complex were also modified by folic acid.•Cytotoxic activity of all nanocomposites together with free complexes was evaluated.•Diphenyltin(IV)-loaded MOFs modified by folate displayed the higher cytotoxic activity. The magnetic metal–organic framework nanocomposite Fe3O4@UiO-66-NH2 was prepared and reacted first with 5, 5′-methylene bis-salicylicaldehyde and then benzhydrazide. In this way, a hydrazone ligand is loaded on the nanocomposite. This functionalized magnetic MOF was reacted with R2SnCl2 (R = Ph, Me) in the presence of triethylamine; thus organotin(IV) complex was immobilized on nanostructures (Fe3O4@UiO-66-SnR2). In order to increase cellular uptake, MOF-based magnetic nanocomposites carrying organotin(IV) complex were also modified by folic acid (Fe3O4@UiO-66-SnR2-FA). All synthesized nanomaterials were characterized using FT-IR, FE-SEM, HRTEM, EDX, XRD, VSM, and TGA techniques. Then, the in vitro cytotoxicity of nanocomposites as well as free hydrazonic ligand and organotin(IV) complexes were evaluated against HT-29, A549 and Hela cell lines using the MTT method. Based on the results, folate-modified targeted systems show more cytotoxic activity than others, and the highest activity was observed for Fe3O4@UiO-66-SnPh2-FA against HeLa cells.