Ultrasound-assisted synthesis of MWCNT /Fe3O4/Cu(BDC) nanocomposite: An efficient fast-release antibacterial carrier for potential suppository administration

• Published in: Materials chemistry and physics 2025-02, Vol.332, Article 130283
• Main Authors: Zokaei Golestan, Narges, Javanbakht, Siamak, Nazeri, Mohammad Taghi, Shaabani, Ahmad
• Format: Article
• Language: English
• Subjects: Antibacterial; Gallic acid; Magnetite nanoparticles; Metal-organic frameworks; Multi-wall carbon nanotube; Ultrasound-assisted synthesis
• ISSN: 0254-0584
• DOI: 10.1016/j.matchemphys.2024.130283

In this work, neoteric hybrid nanocomposites were synthesized using an in-situ ultrasound-assisted synthetic approach, incorporating the copper-benzene dicarboxylic acid (Cu-BDC) metal-organic framework (MOF) on the surface of self-assembled multi-walled carbon nanotube (MWCNT) and iron oxide magnetite nanoparticles (Fe3O4 NPs). The synthesized nanocomposite was characterized by different analyses such as FT-IR, SEM, TEM, XRD, VSM, and EDX. The potential of the prepared nanocomposite as an antibacterial drug carrier was investigated in the in-vitro loading and release of gallic acid (GA). The release profile displayed a fast controlled GA release rate (about 75 % in the first 10 h). In addition, the antibacterial assessment revealed that the prepared nanocomposite is effective in inhibiting E. coli (MBC: 128 μg mL−1, MIC: 64 μg mL−1) and S. aureus (MBC: 64 μg mL−1, MIC: 2 μg mL−1) bacteria. It is important to note that the prepared nanocomposite is considered a low-cost, efficient carrier, and environmentally friendly, which can improve and enhance the antibacterial performance of biomolecules. Alternatively, the results illustrate that it could be suggested as a targeted antibacterial system for potential suppository administration. [Display omitted] •The synthesis of nanocomposite Cu(BDC) framework and Fe3O4 NPs on the surface of MWCNT.•A targeted antibacterial system for suppository administration.•A good drug carrier for gallic acid.