Outcomes after Bone Marrow Versus Peripheral Blood Matched Unrelated Donor Hematopoietic Stem Cell Transplantation for Acute Leukemia

• Published in: Blood 2024-11, Vol.144, p.7283-7283
• Main Authors: Mushtaq, Muhammad Umair, Kasaeian, Amir, Chaudhary, Sibgha Gull, Rostami, Tahereh, Khavandgar, Naghmeh, Alemi, Hediyeh, Amin, Muhammad Kashif, Ur Rehman, Aqeeb, Anwar, Iqra, McGuirk, Matthew, Singh, Anurag K., Abhyankar, Sunil, Hamadani, Mehdi, McGuirk, Joseph P., Shahzad, Moazzam
• Format: Article
• Language: English
• ISSN: 0006-4971
• DOI: 10.1182/blood-2024-202317

Background: Allogeneic hematopoietic stem cell transplantation (HCT) is a potential therapy for acute leukemia. Graft source might impact outcomes in patients undergoing matched unrelated donor (MUD) HCT. Our study compared the outcomes after bone marrow (BM) grafts versus peripheral blood stem cell (PBSC) grafts in patients with acute leukemia undergoing MUD HCT. Methods: We conducteda retrospective multicenter analysis, including patients with acute leukemia receiving MUD HCT in the publicly available Center for International Blood and Marrow Transplant (CIBMTR) registry from 2008 to 2018 using the P5702 dataset by Guru Murthy et al. We examined the impact of graft source on post-transplant outcomes, including overall survival (OS), disease-free survival (DFS), relapse, non-relapse mortality (NRM), acute graft versus host disease (GVHD), chronic GVHD, GVHD-free relapse-free survival (GRFS), and engraftment. Patient-, disease- and transplant-related factors were compared between groups using the Chi-square test for categorical variables and the Wilcoxon two-sample test for continuous variables. The median follow-up duration was estimated using the reverse Kaplan-Meier method. Cox proportional hazards regression analyses were performed. The hazard ratios (HR) with 95% confidence intervals (CI) were calculated. Variables with p-values