PHARMACOLOGY OF SCH 11973, N-(2-PHENYLISOPROPYL)-N-p-TOLUENE SULFONYL UREA, A POTENTIAL NEW ANTIANGINAL AGENT1

• Published in: Japanese journal of pharmacology 1977, Vol.27 (6), p.769-779
• Main Authors: ZITOWITZ, Lester, STIMSON, John, WOHL, Arnold J., EHRREICH, Stewart J.
• Format: Article
• Language: English
• ISSN: 0021-5198; 1347-3506
• DOI: 10.1254/jjp.27.769

Antianginal drugs were evaluated on the basis of their ability to protect against subepicardial electrogram changes induced by local ventricular ischemia in anesthetized dogs. Sch 11973 [N-(2-phenylisopropyl)-N-p-toluene sulfonyl urea], a potential new antianginal agent, was also effective against local ventricular ischemia with its maximum effect appearing at 1 mg/kg, i.v. or i.d. and with a duration of at least 2 hours. Nitroglycerin, at a dose of 0.04 mg/kg given bucally, exerted less protection, lasting on the average less than 15 minutes. Protection by propranolol at 1 mg/kg, i.v., was not better than nitroglycerin, but lasted up to one hour, while dipyridamole was ineffective when given in a dose range of 0.1-10 mg/kg, i.v. Sch 11973 differed from standard antianginal agents which may act via beta-adrenergic blocking activity or alteration of cardiac or circulatory dynamics since no acute pharmacological changes were observed after Sch 11973 was administered.