Fish-oil supplementation in pregnancy does not reduce the risk of gestational diabetes or preeclampsia123

Background: There is uncertainty regarding the efficacy of increasing n−3 long-chain PUFA (LCPUFA) intake during pregnancy in reducing the risk of gestational diabetes mellitus (GDM) and preeclampsia. Objectives: The objective was to determine whether n−3 LCPUFA supplementation in pregnancy reduces...

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Bibliographic Details
Published in:The American journal of clinical nutrition 2012-06, Vol.95 (6), p.1378-1384
Main Authors: Zhou, Shao J, Yelland, Lisa, McPhee, Andy J, Quinlivan, Julie, Gibson, Robert A, Makrides, Maria
Format: Article
Language:English
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Summary:Background: There is uncertainty regarding the efficacy of increasing n−3 long-chain PUFA (LCPUFA) intake during pregnancy in reducing the risk of gestational diabetes mellitus (GDM) and preeclampsia. Objectives: The objective was to determine whether n−3 LCPUFA supplementation in pregnancy reduces the incidence of GDM or preeclampsia. A secondary objective was to assess the effect of n−3 LCPUFA supplementation on perinatal complications. Design: This was a double-blind, multicenter randomized control trial—the DHA to Optimize Mother Infant Outcome (DOMInO) trial. Pregnant women (n = 2399) of
ISSN:0002-9165
1938-3207
DOI:10.3945/ajcn.111.033217