Suppression of Fas expression in the hypertensive placental histology of rats given Nano herbal of Rhodomyrtus tomentosa leaves

High blood pressure during pregnancy can signal a high-risk pregnancy and result in difficulties. The expression of Fas is critical for maintaining hypertensive immunity. Fas is prevalent in the trophoblast, which enhances maternal-derived apoptosis. Because it contains acylphloroglucinol, flavonoid...

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Bibliographic Details
Published in:Kuwait journal of science 2023, Vol.50 (1 A), p.1-16
Main Authors: Situmorang, Putri Cahaya, Syahputra, Rony A., Simanullang, Rostime H.
Format: Article
Language:English
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Summary:High blood pressure during pregnancy can signal a high-risk pregnancy and result in difficulties. The expression of Fas is critical for maintaining hypertensive immunity. Fas is prevalent in the trophoblast, which enhances maternal-derived apoptosis. Because it contains acylphloroglucinol, flavonoids, tannins, and triterpenes, Rhodomyrtus tomentosa (haramonting) is commonly used in traditional Indonesian medicine to treat high blood pressure. The goal was to determine and investigate the role of haramonting in lowering Fas expression in hypertensive rats' placental histopathology. The rats were confirmed to be pregnant were divided into five treatments: (a) normal pregnant rats (control), (b) hypertensive rats (c) hypertensive rats + 100mg/KgBW NRT, (d) hypertensive rats + 200mg/KgBW NRT, and (e) hypertensive rats + 400mg/KgBW NRT. On gestation day 20, pregnant rats were euthanized under ketamine anaesthesia. ELISA was used to examine the expression of the HSP family. Immunohistochemistry was used to assess Fas expression. In hypertensive rats, NRT can lower systolic and diastolic blood pressure (P
ISSN:2307-4108
2307-4116
DOI:10.48129/kjs.16833