Rare case of spot diagnosis of nephrotic syndrome in a Saudi male

A 26-year-old Saudi male school teacher presented with clinical features of nephritic syndrome. Physical examination revealed loss of subcutaneous fat over the face and upper arms (partial lip dystrophy) and druse in both eyes. The serum level of complement C3 was low, with normal C4. Renal biopsy r...

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Bibliographic Details
Published in:Saudi journal of kidney diseases and transplantation 2011-09, Vol.22 (5), p.1003-1007
Main Authors: Askar, A., Mushtaq, F., al-Shuaibi, F., Mustafa, M., Bappu, A.
Format: Article
Language:English
Subjects:
Adult
Biopsy
Case studies
Complement C3 - analysis
Development and progression
Diagnosis
Diseases
Drug therapy
Glomerulonephritis, Membranoproliferative - complications
Glomerulonephritis, Membranoproliferative - diagnosis
Humans
Kidneys
Male
Nephrotic syndrome
Nephrotic Syndrome - diagnosis
Nephrotic Syndrome - drug therapy
Physical Examination
Retinal Drusen - complications
Saudi Arabia
Subcutaneous Fat
الأمراض
التشخيص
الكلى
المتلازمة الكلوية
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Summary:A 26-year-old Saudi male school teacher presented with clinical features of nephritic syndrome. Physical examination revealed loss of subcutaneous fat over the face and upper arms (partial lip dystrophy) and druse in both eyes. The serum level of complement C3 was low, with normal C4. Renal biopsy revealed features consistent with membranoproliferative glomeruli- nephritis (MPGN) type II [Dense Deposit Disease (DDD)]. He was treated with prednisolone and mycophenolate moiety with partial remission. He also received Lipitor and lisinopril. The occurrence of partial lipo-dystrophy and druses in a patient with nephritic syndrome provides a rare clinical opportunity of making a bedside diagnosis of type II MPGN even before kidney biopsy.
ISSN:1319-2442
2320-3838