Effect of the quality of water used for dialysis on the efficacy of hemodialysis: A single-center experience from Morocco

• Published in: Saudi journal of kidney diseases and transplantation 2011-05, Vol.22 (3), p.576-580
• Main Authors: Akhmouch, I., Allam, M., Hamzah, Ma, Atif, T., al-Ayoude, M., Bouaiti, E., Bahadi, A., Asserraji, M.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Bacterial Load; Body Weight; C-Reactive Protein - metabolism; Care and treatment; Endotoxins - analysis; Erythropoietin - therapeutic use; Erythropoietin, Recombinant; Female; Health aspects; Hemodialysis; Hemodialysis patients; Hemoglobins - metabolism; Humans; Kidney Failure, Chronic - blood; Kidney Failure, Chronic - therapy; Male; Middle Aged; Morocco; Nutritional Status; Prognosis; Prospective Studies; Renal Dialysis; Ultrafiltration; Water Microbiology; Water quality; Water Supply - standards; Young Adult; المرضى; المياه; جودة المياه; ضبط الجودة; غسيل الكلى
• ISSN: 1319-2442; 2320-3838

The quality of the water used for dialysis has been suggested as a factor causing inflammation in patients on hemodialysis (HD). We therefore conducted this study to identify the effect of quality of the water on nutritional state, inflammation and need for human recombinant erythropoietin (EPO) in patients undergoing HD at Agadir, Morocco. This prospective study included patients on HD for at least one year. The water treatment was done according to the standard protocol, which was followed by additional enhancement of ultrafiltration using an additional polysulfide filter (diastase, Fresenius, Bad Homburg, Germany) before the dialyzer. Water was monitored regularly during the study period to ensure acceptable levels of bacterial count as well as endotoxin levels. Various parameters including dry weight, systolic and diastolic blood pressure (PA) before and after an HD session, need for human recombinant EPO, levels of hemoglobin (Hb), albumin, ferritin, C-reactive protein (CRP), and the dose of dialysis delivered (Kt / V) were measured first at the beginning of the study and thereafter, in the third, sixth and 12th months of the study. The study involved 47 patients, and after 12 months of the study, an improvement in median dry weight (1.2 kg, P = 0017) and a simultaneous median reduction of 20.7 IU / kg / week of EPO, with an in-crease of the median level of Hb, was noted. The results of our study suggest that by improving the biocompatibility of HD with the use of good quality water, patients acquire a better nutritional, inflammatory and hematologic status.