Matricaria chamomilla attenuates cisplatin nephrotoxicity

Matricaria chamomiles are extensively consumed as a tea or tonic. Despite its widespread use as a home remedy, relatively few trials evaluated its benefits in nephro protection. Hence, this study evaluates the protective role of M. chamomile in cisplatin nephrotoxicity rat model. The study was condu...

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Bibliographic Details
Published in:Saudi journal of kidney diseases and transplantation 2012-07, Vol.23 (4), p.765-772
Main Author: Salamah, Raja H. M.
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Care and treatment
Cathepsin D - blood
Chamomile
Chemical properties
Cisplatin
Cisplatin - poisoning
Complications and side effects
Diagnosis
Disease Models, Animal
DNA Fragmentation
Flowers
gamma-Glutamyltransferase - metabolism
German chamomile
Health aspects
Kidney - drug effects
Kidney diseases
Kidney Function Tests
Male
Materia medica, Vegetable
Matricaria
Oxidative Stress - physiology
Phytotherapy
Plant extracts
Plant Leaves
Rats
Rats, Sprague-Dawley
Therapeutic use
البابونج
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Summary:Matricaria chamomiles are extensively consumed as a tea or tonic. Despite its widespread use as a home remedy, relatively few trials evaluated its benefits in nephro protection. Hence, this study evaluates the protective role of M. chamomile in cisplatin nephrotoxicity rat model. The study was conducted on 32 rats divided into four groups. The first group (G1) was injected with saline intra-peritoneal (IP); G2 was injected with 5 mg/kg cisplatin on day 0 of the experiment and repeated four times, with five days free interval. G3 and G4 were injected daily with M. chamomiles (50 mg / kg) IP, starting five days before the experiment (-5 day) ; in addition, G4 was injected with cisplatin. On day 16, animals were scarified and serum and / or kidney tissue was used to determine : (a) kidney function tests (serum urea, creatinine, gamma glutamyl transferase (GGT), NAG, β-gal), (b) oxidative stress indices (NO, LPO), (c) antioxidant activities (SOD, GSH, total thiols), (d) apoptotic indices (Cathepsin D, DNA fragmentation) and (e) mineral (calcium). M. chamomiles significantly increased the body weight, normalized the kidney functions, improved the apoptotic markers, reduced the oxidative stress markers and corrected the hypocalcaemia that resulted from cisplatin nephrotoxicity. M. chamomiles are a promising nephroprotective compound reducing cisplatin nephrotoxicity most probably by its antioxidant activities and inhibition of gamma glutamyl transferase activity.
ISSN:1319-2442
2320-3838
DOI:10.4103/1319-2442.98158