Evaluating kidney damage from vesico-ureteral reflux in children

To review the most relevant clinical studies that evaluate kidney damage in children with primary vesico-ureteral reflux (VUR), we reviewed and compared randomized controlled trials and clinical trials from scientific literature. In these studies, vesico-ureteral reflux was diagnosed by voiding cyst...

Full description

Saved in:
Bibliographic Details
Published in:Saudi journal of kidney diseases and transplantation 2009, Vol.20 (1), p.57-68
Main Authors: Zaffanello, M, Franchini, M, Brugnara, M, Fanos, V
Format: Article
Language:English
Subjects:
Adolescent
Anti-Bacterial Agents - therapeutic use
Child
Child, Preschool
Children
Congenital kidney damage
Female
Humans
Infant
Infant, Newborn
Kidney - diagnostic imaging
Kidney - pathology
Kidney Diseases - diagnostic imaging
Kidney Diseases - etiology
Male
Medical research
Medicine, Experimental
Meta-analysis
Pediatric neurology
Primary vesico-ureteral reflux
Radiography
Radionuclide Imaging
Randomized Controlled Trials as Topic
Risk
Technetium Tc 99m Dimercaptosuccinic Acid
Urinary Tract Infections - diet therapy
Urinary Tract Infections - etiology
Vesico-Ureteral Reflux - complications
Vesico-Ureteral Reflux - diagnostic imaging
Vesico-ureteral reflux in children
الأطفال
الأمراض
التشخيص
الجزر المثاني الحالبي
الجهاز العصبي
الضرر
الكلى
طب الأعصاب
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To review the most relevant clinical studies that evaluate kidney damage in children with primary vesico-ureteral reflux (VUR), we reviewed and compared randomized controlled trials and clinical trials from scientific literature. In these studies, vesico-ureteral reflux was diagnosed by voiding cystourethrogram and kidney damage was assessed by either DMSA scan or urography. Relative risk with 95% confidence intervals was calculated using Review Manager Software (The Cochrane Collaboration, 2000). The overall relative risk of kidney damage shown by DMSA scan and urography was statistically higher in children with vesico-ureteral reflux of various degrees than in controls (3.7 times and 2.8 times, respectively). However, in high-grade VUR, the relative risk of congenital kidney damage was 5.6 times that of controls. We conclude that severe VUR is frequently associated with early kidney damage, perhaps with prenatal onset. Progression of kidney damage may depend on the severity of VUR and untreated urinary tract infections. Prevention of congenital kidney damage from severe VUR is possible when there is early intervention, even during fetal growth.
ISSN:1319-2442
2320-3838