Adrenocortical status in infants and children with sepsis and septic shockI

-The benefit from corticosteroids remains controversial in sepsis and septic shock and the presence of adrenal insufficiency (AI) has been proposed to justify steroid use. Aim: To determine adrenal state and its relation with outcome in critical children admitted with sepsis to PICU of Cairo Univers...

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Bibliographic Details
Published in:The Gazette of the Egyptian Paediatric Association 2014, Vol.62 (1), p.16-23
Main Authors: Radi, Hana I., Ali, Yasamin S., Bazaraa, Hafiz, Hafiz, Muna
Format: Article
Language:English
Subjects:
Adrenal glands
Diseases
Infants
الأمراض
الرضع
الغدد الكظرية
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Summary:-The benefit from corticosteroids remains controversial in sepsis and septic shock and the presence of adrenal insufficiency (AI) has been proposed to justify steroid use. Aim: To determine adrenal state and its relation with outcome in critical children admitted with sepsis to PICU of Cairo University, Children Hospital. Methods: Thirty cases with sepsis and septic shock were studied. Cortisol levels (CL) were estimated at baseline and after high-dose short ACTH stimulation in those patients and in 30 matched controls. Absolute AI was defined as basal CL< 7 lg/dl and peak CL< 18 lg/dl. Relative AI was diagnosed if cortisol increment after stimulation is
ISSN:1110-6638
2090-9942