Granulomatous interstitial Nephritis due to tuberculosis-a rare presentation

• Published in: Saudi journal of kidney diseases and transplantation 2009-09, Vol.20 (5), p.842-845
• Main Authors: Sooraj, Yesudas S., Mahaldar, Amol R., Ramakrishnan, Muthiah, Rajappannair, Ajeshkumar, Nalumakkal, Seethalekshmy V., Erode, Elango, Sampathkumar, Krishnaswamy
• Format: Article
• Language: English
• Subjects: Adolescent; Antitubercular Agents - therapeutic use; Biopsy; Combined Modality Therapy; DNA, Bacterial - isolation & purification; Drug Therapy, Combination; Granuloma - microbiology; Granuloma - pathology; Granuloma - therapy; Humans; Male; Mycobacterium tuberculosis - genetics; Mycobacterium tuberculosis - isolation & purification; Nephritis; Nephritis, Interstitial; Nephritis, Interstitial - microbiology; Nephritis, Interstitial - pathology; Nephritis, Interstitial - therapy; Proteinuria - microbiology; Renal Dialysis; Renal Insufficiency - microbiology; Steroids - therapeutic use; Time Factors; Treatment Outcome; Tuberculosis; Tuberculosis, Renal - complications; Tuberculosis, Renal - microbiology; Tuberculosis, Renal - pathology; Tuberculosis, Renal - therapy; الأمراض; الالتهاب; التهاب الكلى الخلالي; الرئتان; الصدر; المسالك البولية; المضاعفات; دراسات الحالة; مرض السل
• ISSN: 1319-2442; 2320-3838

Granulomatous interstitial nephritis (GIN) is an uncommon form of acute interstitial nephritis. We report a young male who presented to us with a rapidly progressing renal failure and massive proteinuria. A renal biopsy revealed GIN, and we were able to demonstrate the presence of tuberculous DNA in the biopsy specimen. The patient was started on anti-tuberculous therapy and steroids besides 11 sessions of hemodialysis. He recovered and is currently doing well. This case highlights an uncommon manifestation of renal tuberculosis, namely massive proteinuria, acute renal failure, and granulomatous interstitial lesions.