Acute renal failure due to lymphomatous infiltration : an unusual presentation

Renal lymphoma occurs most often as a part of a multi-systemic disseminated lymphoma or as a recurrence of the tumor. Renal involvement usually occurs late in the course of the disease and is clinically silent. Acute renal failure (ARF) from lymphomatous infiltration has been described but is quite...

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Bibliographic Details
Published in:Saudi journal of kidney diseases and transplantation 2006, Vol.17 (3), p.395-398
Main Authors: Boussema, Izz al-Din, Laadidi, Jannet, Shatti, Qays, Hulayyil, Imad, Bougrine, Fethi, Bouziani, Ammar, Bin Abd Allah, Najib, Louzir, Bassam, Uthmani, Salah, Herz Allah, Qays
Format: Article
Language:English
Subjects:
Acute Kidney Injury - diagnosis
Acute Kidney Injury - etiology
Acute renal failure
Biopsy
Cancer
Chronic renal failure
Diagnosis, Differential
Fatal Outcome
Female
Humans
Intrarenal infiltration
Kidneys
Liver Neoplasms - complications
Liver Neoplasms - diagnosis
Lymphoma
Lymphoma, B-Cell - complications
Lymphoma, B-Cell - diagnosis
Lymphomas
Middle Aged
Tomography, X-Ray Computed
الأمراض
الأمراض المزمنة
الأورام
السرطان
الغدد اللمفاوية
الفشل الكلوي
الكلى
المضاعفات
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Summary:Renal lymphoma occurs most often as a part of a multi-systemic disseminated lymphoma or as a recurrence of the tumor. Renal involvement usually occurs late in the course of the disease and is clinically silent. Acute renal failure (ARF) from lymphomatous infiltration has been described but is quite rare. We report a 50-year-old Caucasian woman, who presented with features of ARF. Physical examination showed that her arterial blood pressure was 190/100 mm Hg with no lymphadenopathy or hepatosplenomegaly. Her urine output was about 100 ml/day, and urinanalysis revealed + proteinuria and microscopic hematuria. Biochemical findings revealed severely impaired renal function with a serum creatinine of 693 micromol/L. The patient's lactate dehydrogenase was elevated at 632 U/L. An abdominal ultrasound showed bilateral, large non-obstructed kidneys and a hypoechoic mass arising in the right lobe of the liver. An ultrasound-guided percutaneous liver biopsy showed typical features of B-cell lymphoblastic lymphoma. The patient expired two days later, even before any specific treatment could be started.
ISSN:1319-2442
2320-3838