Antiadhesive Property of Photoreactive Azidophenyl Low-Molecular-Weight Chitosan in Rabbit Laminotomy Model

Newly developed photoreactive azidophenyl chitosan (P-ALMC) has characteristics of a transformable gel type and its outer layer could be sealed up like a film after UV radiation. We aim to evaluate the antiadhesive properties of P-ALMC through comparing it with hyaluronic acid-carboxymethylcellulose...

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Bibliographic Details
Published in:Journal of chemistry 2013, Vol.2013 (2013), p.1-8
Main Authors: Kang, Hyun, Kim, Jong Won, Son, Tae Il, Kim, Mi Kyung, Jang, Eui-Chan, Song, Kwang-Sup
Format: Article
Language:English
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Summary:Newly developed photoreactive azidophenyl chitosan (P-ALMC) has characteristics of a transformable gel type and its outer layer could be sealed up like a film after UV radiation. We aim to evaluate the antiadhesive properties of P-ALMC through comparing it with hyaluronic acid-carboxymethylcellulose membrane (HA-CMC) in a rabbit laminotomy model. Laminotomies were performed at the L3-4, L4-5, and L5-6 levels in 41 rabbits and each level was randomly assigned to either receive saline (group I), HA-CMC (group II), or P-ALMC (group III). The extent of peridural fibrosis, density of fibroblasts and inflammatory cells, and dural thickness were evaluated at 6 and 12 weeks postoperatively. In the groups II and III, the extents of peridural fibrosis and dural thickness were significantly smaller than those in group I (P
ISSN:2090-9063
2090-9071