Chronic Deep Brain Stimulation of the Hypothalamic Nucleus in Wistar Rats Alters Circulatory Levels of Corticosterone and Proinflammatory Cytokines

Deep brain stimulation (DBS) is a therapeutic option for several diseases, but its effects on HPA axis activity and systemic inflammation are unknown. This study aimed to detect circulatory variations of corticosterone and cytokines levels in Wistar rats, after 21 days of DBS-at the ventrolateral pa...

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Bibliographic Details
Published in:Clinical & developmental immunology 2013, Vol.2013 (2013), p.1-9
Main Authors: Calleja-Castillo, Juan Manuel, De La Cruz-Aguilera, Dora Luz, Manjarrez, Joaquín, Velasco-Velázquez, Marco Antonio, Morales-Espinoza, Gabriel, Moreno-Aguilar, Julia, Hernández, María Eugenia, Aguirre-Cruz, Lucinda, Pavon, Lenin
Format: Article
Language:English
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Summary:Deep brain stimulation (DBS) is a therapeutic option for several diseases, but its effects on HPA axis activity and systemic inflammation are unknown. This study aimed to detect circulatory variations of corticosterone and cytokines levels in Wistar rats, after 21 days of DBS-at the ventrolateral part of the ventromedial hypothalamic nucleus (VMHvl), unilateral cervical vagotomy (UCVgX), or UCVgX plus DBS. We included the respective control (C) and sham (S) groups (n=6 rats per group). DBS treated rats had higher levels of TNF-α (120%; P
ISSN:1740-2522
1740-2530