A Novel Four-Component Reaction between Secondary Amines and Hydroxybenzaldehydes with Isocyanides in Water : An Efficient One-Pot and Green Synthesis of Benzo[b]furan Derivatives

The novel benzo[b]furan derivatives, 7a–i, were synthesized and characterized by Ugi four-component reaction between 2-hydroxybenzaldehyde derivative 1, a secondary amine 2, and an isocyanide 3 in water. Those reactions were carried out at room temperature with moderate to good yields in one pot.

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Bibliographic Details
Published in:Journal of chemistry 2013, Vol.2013 (2013), p.1-5
Main Authors: Vessally, Esmail, Ramazani, Ali, Shabrendi, Hana, Ghadimi, Roghaie, Rouhani, Morteza
Format: Article
Language:English
Online Access:Get full text
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Summary:The novel benzo[b]furan derivatives, 7a–i, were synthesized and characterized by Ugi four-component reaction between 2-hydroxybenzaldehyde derivative 1, a secondary amine 2, and an isocyanide 3 in water. Those reactions were carried out at room temperature with moderate to good yields in one pot.
ISSN:2090-9063
2090-9071