PD-L1 Expression Induced by the 2009 Pandemic Influenza A(H1N1) Virus Impairs the Human T Cell Response

PD-L1 expression plays a critical role in the impairment of T cell responses during chronic infections; however, the expression of PD-L1 on T cells during acute viral infections, particularly during the pandemic influenza virus (A(H1N1)pdm09), and its effects on the T cell response have not been wid...

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Published in:Clinical & developmental immunology 2013, Vol.2013 (2013), p.1-11
Main Authors: Valero-Pacheco, Nuriban, Arriaga-Pizano, Lourdes, Ferat-Osorio, Eduardo, Mora-Velandia, Luz María, Pastelin-Palacios, Rodolfo, Villasís-Keever, Miguel Ángel, Alpuche-Aranda, Celia, Sánchez-Torres, Luvia Enid, Isibasi, Armando, Bonifaz, Laura, López-Macías, Constantino
Format: Article
Language:English
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Summary:PD-L1 expression plays a critical role in the impairment of T cell responses during chronic infections; however, the expression of PD-L1 on T cells during acute viral infections, particularly during the pandemic influenza virus (A(H1N1)pdm09), and its effects on the T cell response have not been widely explored. We found that A(H1N1)pdm09 virus induced PD-L1 expression on human dendritic cells (DCs) and T cells, as well as PD-1 expression on T cells. PD-L1 expression impaired the T cell response against A(H1N1)pdm09 by promoting CD8+ T cell death and reducing cytokine production. Furthermore, we found increased PD-L1 expression on DCs and T cells from influenza-infected patients from the first and second 2009 pandemic waves in Mexico City. PD-L1 expression on CD8+ T cells correlated inversely with T cell proportions in patients infected with A(H1N1)pdm09. Therefore, PD-L1 expression on DCs and T cells could be associated with an impaired T cell response during acute infection with A(H1N1)pdm09 virus.
ISSN:1740-2522
1740-2530